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Association between the CYP1A2 polymorphisms and risk of cancer: a meta-analysis.

Abstract
The previously published data on the association between CYP1A2*1C (rs2069514) and CYP1A2*1F (rs762551) polymorphisms and cancer risk have remained controversial. Hence, we performed a meta-analysis to investigate the association between CYP1A2*1F and CYP1A2*1C polymorphisms and cancer risk under different inheritance models. Overall, significant association was observed between CYP1A2*1F and cancer risk when all the eligible studies were pooled into the meta-analysis (dominant model: OR 1.08, 95 % CI 1.02-1.15; heterozygous model: OR 1.06, 95 % CI 1.01-1.12; additive model: OR 1.07, 95 % CI 1.02-1.13). In the further stratified and sensitivity analyses, for CYP1A2*1F polymorphism, significantly increased lung cancer risk and significantly decreased bladder cancer risk were observed in Caucasians. For CYP1A2*1C polymorphism, no significant association was found in overall and all subgroup analyses. In summary, this meta-analysis suggests that CYP1A2*1F polymorphism is associated with lung cancer and bladder cancer risk in Caucasians.
AuthorsWen-Xia Sun, Ying-Hua Chen, Zhi-Zhong Liu, Jian-Jun Xie, Wei Wang, Ya-Ping Du, Yu Chen, Xu-Liang Shen, Xiao-Feng He, Li-Xia Wu, Wu Wei, Lin Zhang
JournalMolecular genetics and genomics : MGG (Mol Genet Genomics) Vol. 290 Issue 2 Pg. 709-25 (Apr 2015) ISSN: 1617-4623 [Electronic] Germany
PMID25472037 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
Chemical References
  • CYP1A2 protein, human
  • Cytochrome P-450 CYP1A2
Topics
  • Case-Control Studies
  • Cytochrome P-450 CYP1A2 (genetics)
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Lung Neoplasms (genetics)
  • Polymorphism, Single Nucleotide
  • Risk
  • Urinary Bladder Neoplasms (genetics)

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