The comparison of serum vaspin and visfatin concentrations in obese and normal weight women.

Abstract

BACKGROUND AND OBJECTIVES:

There is evidence based studies which show that plasma level of visfatin and vaspin in patients with type 2 diabetes mellitus elevate in comparison with healthy people. But there is no consistency in plasma visfatin and vaspin concentration between studies done on obese people. For this reason, the aim of this study is to investigate the serum level concentrations of visfatin and vaspin in obese women compared to normal weight women.

MATERIALS AND METHODS:

The participants of this study consist of 43 women aged 20-50, and 43 healthy women with normal weight as a control group. They were matched for age and physical activity. 24h food recall was used to collect dietary information from subjects. Moreover, blood sampling was taken to measure the blood levels of sugar, lipid profile, vaspin and visfatin.

RESULTS:

The mean serum level of visfatin was not statistically different between obese and normal weight women. But, the obese women had statistically higher mean serum level of vaspin than normal women (p=0.04). We found no relations between serum levels of vaspin with serum concentration of visfatin. Also, serum levels of these two adipokines were not related to the serum concentrations of fasting glucose, total cholesterol, low-density lipoprotein cholesterol and triglyserides and high-density lipoprotein cholesterol. Also, there was a significant positive relationship between carbohydrate intake and serum visfatin level in women participating to this study (p=0.018, r=0.257).

CONCLUSION:

The results of this study demonstrated that the level of serum vaspin was significantly higher in obese women. But there were no differences in serum levels of visfatin in comparison to normal weight women. Meanwhile this study demonstrated a positive relationship between serum levels of visfatin with dietary intake of carbohydrate, but no relationship between serum level of visfatin and vaspin in women participating in this study.

• Authors: S Saboori, M J Hosseinzadeh-Attar, E Yousefi Rad, M Hosseini, K Mirzaei, Z Ahmadivand
• Journal: Diabetes & metabolic syndrome (Diabetes Metab Syndr) 2015 Oct-Dec Vol. 9 Issue 4 Pg. 320-3 ISSN: 1878-0334 [Electronic] Netherlands
• PMID: 25470626 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers
• Cytokines
• SERPINA12 protein, human
• Serpins
• Nicotinamide Phosphoribosyltransferase
• nicotinamide phosphoribosyltransferase, human

Topics

• Adult
• Biomarkers (blood)
• Body Mass Index
• Case-Control Studies
• Cytokines (blood)
• Female
• Follow-Up Studies
• Humans
• Insulin Resistance
• Male
• Middle Aged
• Nicotinamide Phosphoribosyltransferase (blood)
• Obesity (blood, epidemiology)
• Prognosis
• Risk Factors
• Serpins (blood)
• Young Adult