Hepatic clearance measured with (99m)Tc-GSA single-photon emission computed tomography to estimate liver fibrosis.

Abstract

AIM:

To evaluate the clinical utility of hepatic clearance (HC) measured with technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl human serum albumin ((99m)Tc-GSA) single-photon emission computed tomography (SPECT) to estimate the degree of liver fibrosis.

METHODS:

Seventy-eight consecutive patients who underwent initial hepatectomy due to hepatocellular carcinoma were enrolled in this study. Indocyanine green clearance (ICG R15), quantitative indices estimated by (99m)Tc-GSA [the receptor index (LHL15 and HH15) and HC via SPECT analysis], and conventional liver function tests were performed before hepatectomy. Correlations among the quantitative indices for liver functional reserve, conventional liver function tests, and the degree of liver fibrosis were evaluated.

RESULTS:

The degree of liver fibrosis was correlated with ICG R15, HH15, LHL15, and HC. HC showed the best correlation with conventional liver function tests. According to multivariate analysis, HC and LHL15 were significant independent predictors of severe fibrosis. HC was the most valuable index for predicting severe fibrosis.

CONCLUSION:

HC measured with (99m)Tc-GSA SPECT is a reliable index for assessing liver fibrosis before hepatectomy.

• Authors: Masahiko Taniguchi, Atsutaka Okizaki, Kenji Watanabe, Koji Imai, Koichiro Uchida, Takahiro Einama, Noriyuki Shuke, Naoyuki Miyokawa, Hiroyuki Furukawa
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 20 Issue 44 Pg. 16714-20 (Nov 28 2014) ISSN: 2219-2840 [Electronic] United States
• PMID: 25469042 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Fluorescent Dyes
• Radiopharmaceuticals
• Technetium Tc 99m Aggregated Albumin
• technetium Tc 99m DTPA-galactosyl-human serum albumin
• Indocyanine Green
• Technetium Tc 99m Pentetate

Topics

• Aged
• Area Under Curve
• Female
• Fluorescent Dyes
• Hepatectomy
• Hepatobiliary Elimination
• Humans
• Indocyanine Green
• Liver (diagnostic imaging, metabolism, physiopathology, surgery)
• Liver Cirrhosis (diagnostic imaging, metabolism, physiopathology, surgery)
• Liver Function Tests
• Male
• Middle Aged
• Multivariate Analysis
• Predictive Value of Tests
• ROC Curve
• Radiopharmaceuticals (pharmacokinetics)
• Regression Analysis
• Retrospective Studies
• Severity of Illness Index
• Technetium Tc 99m Aggregated Albumin (pharmacokinetics)
• Technetium Tc 99m Pentetate (pharmacokinetics)
• Tomography, Emission-Computed, Single-Photon