A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilatation in post corrosive esophageal stricture in children.

Abstract

OBJECTIVES:

The aim of this study is to investigate the efficacy of topical application of mitomycin C after dilation in pediatric patients having post corrosive esophageal stricture.

METHODS:

Thirty patients with post corrosive esophageal strictures were divided into two groups: 12 patients had repeated esophageal dilation without mitomycin C application, 18 patients had repeated esophageal dilation and topical application of mitomycin C.

RESULTS:

There was a highly significant difference in the improvement of dysphagia grade at the end of follow up in the mitomycin C group (p=0.005). The number of repetition of dilatation ranged from 2 to 6 (median=3) in the 1st group, and 2 to 4 (median=2.5) in the mitomycin C group. There were no adverse effects from the topical application of the mitomycin C.

CONCLUSIONS:

Topical application of mitomycin C after oesophageal dilation can be beneficial in improving dysphagia in patients with post corrosive oesophageal stricture.

• Authors: Ahmed S Sweed, Samya A Fawaz, Waleed F Ezzat, Sabri M Sabri
• Journal: International journal of pediatric otorhinolaryngology (Int J Pediatr Otorhinolaryngol) Vol. 79 Issue 1 Pg. 23-5 (Jan 2015) ISSN: 1872-8464 [Electronic] Ireland
• PMID: 25465445 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antibiotics, Antineoplastic
• Caustics
• Mitomycin

Topics

• Administration, Topical
• Antibiotics, Antineoplastic (therapeutic use)
• Burns, Chemical (complications)
• Caustics
• Child
• Child, Preschool
• Deglutition Disorders (etiology, therapy)
• Dilatation
• Esophageal Stenosis (etiology, therapy)
• Esophagoscopy
• Female
• Humans
• Male
• Mitomycin (therapeutic use)
• Prospective Studies
• Severity of Illness Index