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Serotonin transporter availability in thalamic subregions in schizophrenia: a study using 7.0-T MRI with [(11)C]DASB high-resolution PET.

Abstract
The serotonin transporter (SERT) is an integral protein that provides an index of serotonergic innervation. Until recently, few studies have investigated SERT binding in thalamic subregions in schizophrenia. The purpose of this study was to examine SERT availability in thalamic subdivisions (anterior nucleus, mediodorsal nucleus, and pulvinar) using 7.0-T magnetic resonance imaging (MRI) and high-resolution positron emission tomography (PET) with (11)C-3-amino-4-(2-dimethylaminomethylphenylthio)benzonitrile ([(11)C]DASB) in schizophrenia. Antipsychotic-free patients with schizophrenia (n=12) and healthy controls (n=15) underwent PET and MRI scans. For SERT availability, the binding potential with respect to non-displaceable compartment (BPND) was derived using the simplified reference tissue model (SRTM2). The analysis revealed that there were no significant differences in SERT availability between the two groups. In patients with schizophrenia, the severity of negative symptoms had a negative correlation with SERT availability in the anterior nucleus of the left thalamus. The present study did not reveal significant differences in SERT availability in thalamic subdivisions between patients with schizophrenia and control subjects. The association of SERT availability in the anterior nucleus with negative symptoms may suggest a role for the anterior thalamic nucleus in the pathophysiology of symptoms of schizophrenia. The ultra-high resolution imaging system could be an important asset for in vivo psychiatric research by combining structural and molecular information.
AuthorsJong-Hoon Kim, Young-Don Son, Jeong-Hee Kim, Eun-Jung Choi, Sang-Yoon Lee, Jee Eun Lee, Zang-Hee Cho, Young-Bo Kim
JournalPsychiatry research (Psychiatry Res) Vol. 231 Issue 1 Pg. 50-7 (Jan 30 2015) ISSN: 1872-7123 [Electronic] Ireland
PMID25465315 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile
  • Aniline Compounds
  • Membrane Transport Proteins
  • Serotonin Plasma Membrane Transport Proteins
  • Sulfides
Topics
  • Adult
  • Aniline Compounds
  • Brain (drug effects, metabolism)
  • Case-Control Studies
  • Female
  • Humans
  • Image Processing, Computer-Assisted (methods)
  • Magnetic Resonance Imaging
  • Male
  • Membrane Transport Proteins (metabolism)
  • Middle Aged
  • Positron-Emission Tomography
  • Schizophrenia (diagnostic imaging, metabolism)
  • Serotonin Plasma Membrane Transport Proteins (metabolism)
  • Sulfides
  • Thalamus (metabolism)

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