Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats.

Abstract	The effect of intravenous injections (0.1-3 nmol/kg) of platelet-activating factor (PAF) on blood pressure, heart rate, cardiac output, and blood flow (hindquarter, renal, mesenteric) were studied in conscious rats. PAF decreased blood pressure and total peripheral resistance (TPR) but increased heart rate; cardiac output was reduced by the highest dose. Low doses of PAF increased blood flow and decreased vascular resistance in all vascular beds, whereas high doses reduced mesenteric blood flow in part by increasing mesenteric vascular resistance. The hypotensive and cardiac effects of PAF were blocked by intravenous infusions of the selective PAF-receptor antagonists, 15 mg/kg BN 52021 and 1 mg/kg SDZ 63-441. BN 52021 also attenuated the hindquarter and renal responses to PAF, but the mesenteric responses remained relatively unchanged. The results indicate that PAF is a potent vasodilator of mesenteric greater than hindquarter = renal vessels at low doses and a cardiac depressant at high doses. A therapeutic role for the PAF antagonists BN 52021 and SDZ 63-441 is suggested in endotoxemia, anaphylaxis, and other disease states in which increased release of PAF contributes to key hemodynamic derangements.
Authors	A L Sirén, G Feuerstein
Journal	The American journal of physiology (Am J Physiol) Vol. 257 Issue 1 Pt 2 Pg. H25-32 (Jul 1989) ISSN: 0002-9513 [Print] United States
PMID	2546449 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Arachidonic Acids Diterpenes Ginkgolides Lactones Platelet Activating Factor Platelet Membrane Glycoproteins Receptors, Cell Surface Receptors, G-Protein-Coupled platelet activating factor receptor Arachidonic Acid ginkgolide B
Topics	Animals Arachidonic Acid Arachidonic Acids (metabolism) Diterpenes Dose-Response Relationship, Drug Ginkgolides Hemodynamics (drug effects) Lactones (pharmacology) Male Platelet Activating Factor (antagonists & inhibitors, pharmacology) Platelet Membrane Glycoproteins Rats Rats, Inbred Strains Receptors, Cell Surface (drug effects) Receptors, G-Protein-Coupled Regional Blood Flow (drug effects) Vascular Resistance (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!