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Low molecular weight heparin Novo (LHN-1) does not cross the placenta during the second trimester of pregnancy.

Abstract
Unfractionated heparin (UF-H) has been the drug of choice for the treatment of thromboembolic disorders during pregnancy. Low molecular weight heparin (LMW-H) preparations may present some advantages over UF-H. They have longer half-lives and a better bioavailability after subcutaneous (s. c.) injection and may cause less bleeding. It has not yet been established whether LMW-H Novo (LHN-1) crosses the placenta. 17 women admitted for abortion during the second trimester of pregnancy (induced by application of prostaglandine PGE2 gel at a concentration of 0.25 mg/ml into the cervix) were given s. c. 35 anti-Xa units per kg of body weight of LHN-1 (Novo). 10 patients not receiving LHN-1 and their fetuses served as a control group. 7 women in whom the time interval between injection of LHN-1 and expulsion of the fetus was less than 3 h or more than 7 h were excluded from further study. In one fetus blood collection failed. Anti-Xa and anti-IIa levels increased approximately ten-fold in women receiving LHN-1 [anti-Xa units/ml from 0.02 +/- 0.01 (mean +/- SD) to 0.17 +/- 0.01, p less than 0.001; anti-Ha units/ml from less than 0.01 +/- 0.01 to 0.07 +/- 0.03], but remained below the detection limit in their fetuses as well as in the women and fetuses of the control group. We conclude that LHN-1 at these doses does not cross the placenta during the second trimester of pregnancy to suggest that LHN-1 may be a safe alternative to heparin in the management of the thromboembolic complications during pregnancy.
AuthorsA Omri, J F Delaloye, H Andersen, F Bachmann
JournalThrombosis and haemostasis (Thromb Haemost) Vol. 61 Issue 1 Pg. 55-6 (Feb 28 1989) ISSN: 0340-6245 [Print] Germany
PMID2546279 (Publication Type: Journal Article)
Chemical References
  • Heparin, Low-Molecular-Weight
  • Serine Proteinase Inhibitors
  • Prothrombin
  • Factor IIa
  • Factor Xa
Topics
  • Abortion, Induced
  • Adolescent
  • Adult
  • Factor Xa
  • Female
  • Fetal Blood (analysis)
  • Heparin, Low-Molecular-Weight (pharmacokinetics)
  • Humans
  • Maternal-Fetal Exchange
  • Pregnancy
  • Pregnancy Trimester, Second
  • Prothrombin (antagonists & inhibitors)
  • Serine Proteinase Inhibitors

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