[Prevention of hypotension during spinal anesthesia for elective caesarean section: coloading with HAE 130/0.4 vs normal saline solution].

Abstract

OBJECTIVE:

The aim of this study was to compare the efficacy of HES 130/0.4 coloading compared to normal saline solution for prevention of hypotension during spinal anesthesia for elective caesarean section.

STUDY DESIGN:

Prospective, randomized.

PATIENTS AND METHODS:

One hundred and twenty ASA I and II patients scheduled for elective caesarean section were recruited. Patients were randomized to receive either 500mL of HES 130/0.4 (Voluven(®)) coloading (GroupV) or 500mL of normal saline solution coloading (GroupC). Spinal anesthesia technique and ephedrine administration were standardized in both groups. The primary endpoint was the incidence of maternal hypotension during spinal anesthesia for elective caesarean section.

RESULTS:

Hypotension occurred in 43 patients in group C and 24 patients in group V (p=0.001). Ephedrine consumption was significantly lower in group V (P=0.005). Nausea, vomiting and headache incidence was higher in group C (p=0.006). Apgar scores and umbilical blood gazes were comparable between groups.

CONCLUSION:

HES 130/0.4 coload was more effective than normal saline solution to prevent hypotension following spinal anesthesia for elective cesarean section. HES 130/0.4 coload reduced the incidence, the duration of longest hypotension, the need for ephedrine and the adverse maternal effects.

• Authors: L Bennasr, S Ben Marzouk, Z Ajili, A Riahi, M A Jarraya, S Massoudi, H Jabri, H Maghrebi
• Journal: Annales francaises d'anesthesie et de reanimation (Ann Fr Anesth Reanim) Vol. 33 Issue 12 Pg. 643-7 (Dec 2014) ISSN: 1769-6623 [Electronic] France
• Vernacular Title: Prévention de l'hypotension induite par la rachianesthésie au cours de la césarienne programmée : coremplissage par HEA 130/0,4 vs sérum salé isotonique.
• PMID: 25458454 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2014 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.

Chemical References

• Hydroxyethyl Starch Derivatives
• Plasma Substitutes
• Vasoconstrictor Agents
• Ephedrine

Topics

• Adult
• Anesthesia, Obstetrical (adverse effects, methods)
• Anesthesia, Spinal (adverse effects, methods)
• Apgar Score
• Blood Gas Analysis
• Cesarean Section (adverse effects, methods)
• Elective Surgical Procedures
• Ephedrine (adverse effects, therapeutic use)
• Female
• Humans
• Hydroxyethyl Starch Derivatives (therapeutic use)
• Hypotension (prevention & control)
• Plasma Substitutes (therapeutic use)
• Pregnancy
• Pregnancy Outcome
• Prospective Studies
• Vasoconstrictor Agents (adverse effects, therapeutic use)