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Different membrane anchors of Fc gamma RIII (CD16) on K/NK-lymphocytes and neutrophils. Protein- vs lipid-anchor.

Abstract
Fc gamma RIII (CD16), the type three receptor for the Fc portion of IgG, is expressed on neutrophils, killer (K)/NK lymphocytes and macrophages. K/NK lymphocyte Fc gamma RIII, which plays a role in antibody-dependent cellular cytotoxicity, is an efficient signal transducing molecule, whereas neutrophil Fc gamma RIII, which plays a role in immune-complex clearance, seems less efficient in signal transduction. Neutrophil Fc gamma RIII has been reported to be a glycan-phosphatidylinositol-anchored membrane protein. Our studies suggest that K/NK lymphocyte Fc gamma RIII is protein-anchored rather than glycan-phosphatidylinositol-anchored. That is, K/NK lymphocyte Fc gamma RIII was resistant to phosphatidylinositol-specific phospholipase C and surface expression of Fc gamma RIII was not affected on K/NK lymphocytes from patients with paroxysmal nocturnal hemoglobinuria, a disorder of hemopoietic stem cells resulting in deficient expression of glycan-phosphatidylinositol-anchored proteins. Different membrane anchoring mechanisms of the Fc gamma RIII may account for different consequences of the ligand binding to two cell types.
AuthorsE Ueda, T Kinoshita, J Nojima, K Inoue, T Kitani
JournalJournal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 143 Issue 4 Pg. 1274-7 (Aug 15 1989) ISSN: 0022-1767 [Print] United States
PMID2545784 (Publication Type: Journal Article)
Chemical References
  • Antigens, Differentiation
  • Immunoglobulin G
  • Membrane Lipids
  • Membrane Proteins
  • Receptors, Fc
  • Receptors, IgG
  • Phosphoric Diester Hydrolases
  • Phosphoinositide Phospholipase C
  • Phosphatidylinositol Diacylglycerol-Lyase
Topics
  • Antigens, Differentiation (metabolism, physiology)
  • Hemoglobinuria, Paroxysmal (blood)
  • Humans
  • Immunoglobulin G (metabolism)
  • Killer Cells, Natural (drug effects, metabolism)
  • Membrane Lipids (metabolism, physiology)
  • Membrane Proteins (metabolism, physiology)
  • Neutrophils (drug effects, metabolism)
  • Phosphatidylinositol Diacylglycerol-Lyase
  • Phosphoinositide Phospholipase C
  • Phosphoric Diester Hydrolases (pharmacology)
  • Receptors, Fc (metabolism, physiology)
  • Receptors, IgG
  • Signal Transduction (drug effects)

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