Abstract |
Fc gamma RIII (CD16), the type three receptor for the Fc portion of IgG, is expressed on neutrophils, killer (K)/NK lymphocytes and macrophages. K/NK lymphocyte Fc gamma RIII, which plays a role in antibody-dependent cellular cytotoxicity, is an efficient signal transducing molecule, whereas neutrophil Fc gamma RIII, which plays a role in immune-complex clearance, seems less efficient in signal transduction. Neutrophil Fc gamma RIII has been reported to be a glycan-phosphatidylinositol-anchored membrane protein. Our studies suggest that K/NK lymphocyte Fc gamma RIII is protein-anchored rather than glycan-phosphatidylinositol-anchored. That is, K/NK lymphocyte Fc gamma RIII was resistant to phosphatidylinositol-specific phospholipase C and surface expression of Fc gamma RIII was not affected on K/NK lymphocytes from patients with paroxysmal nocturnal hemoglobinuria, a disorder of hemopoietic stem cells resulting in deficient expression of glycan-phosphatidylinositol-anchored proteins. Different membrane anchoring mechanisms of the Fc gamma RIII may account for different consequences of the ligand binding to two cell types.
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Authors | E Ueda, T Kinoshita, J Nojima, K Inoue, T Kitani |
Journal | Journal of immunology (Baltimore, Md. : 1950)
(J Immunol)
Vol. 143
Issue 4
Pg. 1274-7
(Aug 15 1989)
ISSN: 0022-1767 [Print] United States |
PMID | 2545784
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Differentiation
- Immunoglobulin G
- Membrane Lipids
- Membrane Proteins
- Receptors, Fc
- Receptors, IgG
- Phosphoric Diester Hydrolases
- Phosphoinositide Phospholipase C
- Phosphatidylinositol Diacylglycerol-Lyase
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Topics |
- Antigens, Differentiation
(metabolism, physiology)
- Hemoglobinuria, Paroxysmal
(blood)
- Humans
- Immunoglobulin G
(metabolism)
- Killer Cells, Natural
(drug effects, metabolism)
- Membrane Lipids
(metabolism, physiology)
- Membrane Proteins
(metabolism, physiology)
- Neutrophils
(drug effects, metabolism)
- Phosphatidylinositol Diacylglycerol-Lyase
- Phosphoinositide Phospholipase C
- Phosphoric Diester Hydrolases
(pharmacology)
- Receptors, Fc
(metabolism, physiology)
- Receptors, IgG
- Signal Transduction
(drug effects)
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