HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

ER stress: how trypanosomes deal with it.

Abstract
An efficient response to endoplasmic reticulum (ER) stress is essential for the viability of eukaryotic cells. The causative agent of African sleeping sickness, Trypanosoma brucei, responds to such stress by inducing spliced leader RNA silencing (SLS), resulting in shutdown of mRNA biogenesis. A new study elucidates the activation cascade and its molecular components, which are unique to the ER stress response in trypanosomes.
AuthorsAlbrecht Bindereif, Christian Preußer
JournalTrends in parasitology (Trends Parasitol) Vol. 30 Issue 12 Pg. 549-50 (Dec 2014) ISSN: 1471-5007 [Electronic] England
PMID25457395 (Publication Type: Journal Article)
CopyrightCopyright © 2014. Published by Elsevier Ltd.
Chemical References
  • RNA, Spliced Leader
Topics
  • Animals
  • Apoptosis
  • Endoplasmic Reticulum Stress (genetics, physiology)
  • Gene Expression Regulation
  • Host-Parasite Interactions
  • Humans
  • RNA Interference
  • RNA, Spliced Leader (genetics)
  • Trypanosoma brucei brucei (genetics, physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: