Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery: a 10-year update.

Abstract

PURPOSE/OBJECTIVES:

Treatment outcomes were analyzed for patients who received radiotherapy for squamous cell carcinoma of the retromolar trigone at a single institution.

MATERIALS/METHODS:

We reviewed the medical records of 110 patients treated with radiotherapy alone (n=36) or radiotherapy combined with surgical resection of the primary tumor (n=74) between June 1966 and October 2013. The median follow-up was 4.5years for all patients and 11.8years for living patients (range, 1.3-23.5years).

RESULTS:

The 5-year local-regional control rates after definitive radiotherapy versus surgery and radiotherapy for stages I-III were 52% and 89% and for stage IV they were 46% and 58%, respectively. The 5-year cause-specific survival rates after definitive radiotherapy compared with surgery and radiotherapy for stages I-III were 57% and 82% and for stage IV they were 45% and 43%, respectively. Multivariate analyses revealed that the likelihood of cure was better with surgery and radiotherapy compared with radiotherapy alone (p=0.041).

CONCLUSION:

Patients treated with surgery and radiotherapy had a better chance of cure than those treated with radiotherapy alone. Complications of treatment were common in both groups but more common in patients who underwent surgery.

• Authors: Kathryn E Hitchcock, Robert J Amdur, Christopher G Morris, John W Werning, Peter T Dziegielewski, William M Mendenhall
• Journal: American journal of otolaryngology (Am J Otolaryngol) 2015 Mar-Apr Vol. 36 Issue 2 Pg. 140-5 ISSN: 1532-818X [Electronic] United States
• PMID: 25456514 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (mortality, pathology, radiotherapy, surgery)
• Cohort Studies
• Combined Modality Therapy
• Disease-Free Survival
• Female
• Follow-Up Studies
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Molar, Third (pathology, surgery)
• Mouth Neoplasms (mortality, pathology, radiotherapy, surgery)
• Multivariate Analysis
• Neoplasm Recurrence, Local (mortality, pathology, therapy)
• Radiotherapy Dosage
• Retrospective Studies
• Risk Assessment
• Survival Analysis
• Treatment Outcome