Colchicine use in isolated renal AA amyloidosis.

Abstract

We present the case of a 45-year-old woman, with two-year history of chronic renal insufficiency and proteinuria. A kidney biopsy showed the presence of AA amyloidosis (positive Congo red staining and immunohistochemistry). There was no evidence of amyloid deposits in other organs and there was no underlying disease. AA amyloidosis normally is secondary to chronic inflammatory or infectious diseases. High levels of IL-1, IL-6 and TNF-α play a role in the pathogenesis of amyloidosis and induce the synthesis of serum amyloid A protein (SAA), a precursor of tissue amyloid deposits. We empirically treated the patient with a low dose colchicine. The patient responded well. Colchicine has been used for the treatment of Familiar Mediterranean Fever and related auto-inflammatory diseases. To monitor treatment responses, we measured SAA finding low titers. Soon after treatment onset there were signs of improvement pertaining to proteinuria and stabilization of renal function.

• Authors: Carlos F Meneses, César A Egües, Miren Uriarte, Joaquín Belzunegui, Marta Rezola
• Journal: Reumatologia clinica (Reumatol Clin) 2015 Jul-Aug Vol. 11 Issue 4 Pg. 242-3 ISSN: 1885-1398 [Electronic] Spain
• PMID: 25453598 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

Chemical References

• Tubulin Modulators
• Colchicine

Topics

• Amyloidosis (diagnosis, drug therapy)
• Colchicine (therapeutic use)
• Female
• Humans
• Kidney Diseases (diagnosis, drug therapy)
• Middle Aged
• Tubulin Modulators (therapeutic use)