Abstract | BACKGROUND: METHODS AND MATERIALS: In this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "group A", who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet; "group B",who received olive oil; and "group C", who received the co-supplemented oils. Clinically, EDSS as well as serum level of liver enzymes (GGT, AST, and ALT) were assessed at baseline and after 6 months. RESULTS: Mean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration of 6.80±4.33 years). There was no significant difference in the study parameters at baseline. Serum levels of liver enzymes (GGT, AST, and ALT) were serially monitored. Intervention was associated with liver function alteration in three groups. Significance decreased in EDSS score and the levels of liver enzymes were found in groups A and C, whereas elevated serum liver enzymes and EDSS score were observed in group B after the intervention. CONCLUSION: Selecting foods according to their Total antioxidant capacity such as co-supplemented hemp seed and evening primrose oils with Hot-nature diet affects antioxidant intake and can have beneficial effects on improving EDSS score and activity of liver enzymes in RRMS patients.
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Authors | Soheila Rezapour-Firouzi, Seyed Rafie Arefhosseini, Mehrangiz Ebrahimi-Mamaghani, Behzad Baradaran, Elyar Sadeghihokmabad, Mohammadali Torbati, Somaiyeh Mostafaei, Mahtaj Chehreh, Fatemeh Zamani |
Journal | Complementary therapies in medicine
(Complement Ther Med)
Vol. 22
Issue 6
Pg. 986-93
(Dec 2014)
ISSN: 1873-6963 [Electronic] Scotland |
PMID | 25453518
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Linoleic Acids
- Plant Oils
- evening primrose oil
- gamma-Linolenic Acid
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Topics |
- Adolescent
- Adult
- Cannabis
- Double-Blind Method
- Female
- Humans
- Linoleic Acids
(administration & dosage)
- Liver
(drug effects, enzymology)
- Male
- Middle Aged
- Multiple Sclerosis
(diet therapy, enzymology)
- Oenothera biennis
- Plant Oils
(administration & dosage)
- Seeds
- Young Adult
- gamma-Linolenic Acid
(administration & dosage)
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