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The use of paralytics in patients with acute respiratory distress syndrome.

Abstract
Interest in the role of neuromuscular blocking agents (NMBAs) in the treatment of acute respiratory distress syndrome (ARDS) has been renewed since a recent randomized clinical trial showed a reduction in mortality associated with the use of NMBAs. However, the role of paralytics in a protective mechanical ventilation strategy should be detailed. This review summarizes data in the literature concerning the clinical effects of NMBAs on the outcome of patients with ARDS, in an attempt to explain some pathophysiologic hypotheses concerning their action and to integrate them into the overall management strategy for the mechanical ventilation of ARDS patients.
AuthorsSami Hraiech, Stéphanie Dizier, Laurent Papazian
JournalClinics in chest medicine (Clin Chest Med) Vol. 35 Issue 4 Pg. 753-63 (Dec 2014) ISSN: 1557-8216 [Electronic] United States
PMID25453423 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Neuromuscular Blocking Agents
Topics
  • Critical Care
  • Drug Administration Schedule
  • Humans
  • Neuromuscular Blocking Agents (administration & dosage, adverse effects)
  • Respiration, Artificial
  • Respiratory Distress Syndrome (drug therapy)

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