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Nausea: current knowledge of mechanisms, measurement and clinical impact.

Abstract
Nausea is a subjective sensation, which often acts as a signal that emesis is imminent. It is a widespread problem that occurs as a clinical sign of disease or as an adverse effect of a drug therapy or surgical procedure. The mechanisms of nausea are complex and the neural pathways are currently poorly understood. This review summarises the current knowledge of nausea mechanisms, the available animal models for nausea research and the anti-nausea properties of commercially available anti-emetic drugs. The review also presents subjective assessment and scoring of nausea. A better understanding of the underlying mechanisms of nausea might reveal potential clinically useful biomarkers for objective measurement of nausea in species of veterinary interest.
AuthorsHannah Kenward, Ludovic Pelligand, Karine Savary-Bataille, Jonathan Elliott
JournalVeterinary journal (London, England : 1997) (Vet J) Vol. 203 Issue 1 Pg. 36-43 (Jan 2015) ISSN: 1532-2971 [Electronic] England
PMID25453240 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
Chemical References
  • Antiemetics
Topics
  • Animals
  • Antiemetics (therapeutic use)
  • Brain (physiology)
  • Nausea (drug therapy, etiology, veterinary)
  • Vomiting (drug therapy, etiology, veterinary)

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