HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Histone H3.3 and cancer: A potential reader connection.

Abstract
The building block of chromatin is nucleosome, which consists of 146 base pairs of DNA wrapped around a histone octamer composed of two copies of histone H2A, H2B, H3, and H4. Significantly, the somatic missense mutations of the histone H3 variant, H3.3, are associated with childhood and young-adult tumors, such as pediatric high-grade astrocytomas, as well as chondroblastoma and giant-cell tumors of the bone. The mechanisms by which these histone mutations cause cancer are by and large unclear. Interestingly, two recent studies identified BS69/ZMYND11, which was proposed to be a candidate tumor suppressor, as a specific reader for a modified form of H3.3 (H3.3K36me3). Importantly, some H3.3 cancer mutations are predicted to abrogate the H3.3K36me3/BS69 interaction, suggesting that this interaction may play an important role in tumor suppression. These new findings also raise the question of whether H3.3 cancer mutations may lead to the disruption and/or gain of interactions of additional cellular factors that contribute to tumorigenesis.
AuthorsFei Lan, Yang Shi
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 112 Issue 22 Pg. 6814-9 (Jun 02 2015) ISSN: 1091-6490 [Electronic] United States
PMID25453099 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Carrier Proteins
  • Cell Cycle Proteins
  • Co-Repressor Proteins
  • DNA-Binding Proteins
  • Histones
  • ZMYND11 protein, human
Topics
  • Carrier Proteins (metabolism)
  • Cell Cycle Proteins
  • Co-Repressor Proteins
  • DNA-Binding Proteins
  • Gene Expression Regulation, Neoplastic (physiology)
  • Histones (genetics, metabolism)
  • Humans
  • Models, Biological
  • Mutation, Missense (genetics)
  • Neoplasms (metabolism)
  • Protein Structure, Tertiary

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: