Chromogranins--new sensitive markers for neuroendocrine tumors.

Abstract

Chromogranins A, B and C, proteins that are costored and coreleased with peptides and amines, have been identified in a variety of endocrine and nervous tissues, both normal and neoplastic. We examined the secretion of chromogranin A and chromogranin A + B by hormone-producing tumors in patients with endocrine pancreatic tumors (EPT), carcinoid tumors, pheochromocytomas and small cell lung cancer (SCLC). Radioimmunoassay (RIA) of the plasma/serum concentrations of chromogranin A + B showed a greater sensitivity than RIA of chromogranin A alone. All patients with EPT, carcinoids and pheochromocytomas had increased levels of chromogranin A + B, whereas a small number of the patients (5/18 with EPT and 1/3 with pheochromocytomas) had normal levels of chromogranin A. Also in immunocytochemical stainings, our polyclonal antiserum detecting both chromogranin A and B showed a greater sensitivity than other available antisera against chromogranin A, B and C.

• Authors: B Eriksson, H Arnberg, K Oberg, U Hellman, G Lundqvist, C Wernstedt, E Wilander
• Journal: Acta oncologica (Stockholm, Sweden) (Acta Oncol) Vol. 28 Issue 3 Pg. 325-9 ( 1989) ISSN: 0284-186X [Print] England
• PMID: 2545231 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Chromogranins
• Nerve Tissue Proteins

Topics

• Adenoma, Islet Cell (metabolism)
• Adrenal Gland Neoplasms (metabolism)
• Biomarkers, Tumor (analysis)
• Carcinoid Tumor (metabolism)
• Carcinoma, Small Cell (metabolism)
• Chromogranins (analysis)
• Female
• Humans
• Immunohistochemistry
• Lung Neoplasms (metabolism)
• Male
• Neoplasms (metabolism)
• Neoplasms, Nerve Tissue (metabolism)
• Nerve Tissue Proteins (analysis)
• Pancreatic Neoplasms (metabolism)
• Radioimmunoassay