Antiherpes activity of chemically synthesized lipid A-subunit analogue GLA-60 in immunosuppressed mice.

Intraperitoneal administration of 10 micrograms GLA-60, a chemically synthesized lipid A analogue, to mice one day after treatment with 200 mg/kg of cyclophosphamide (CY) significantly increased the number of macrophages, lymphocytes and polymorphonuclear leukocytes (PMNs) in the peritoneal cavity. The intrinsic antiviral activity of macrophages against herpes simplex virus type 1 (HSV-1) as well as natural killer (NK) activity against YAC-1 target cells was stimulated by administration of GLA-60 to CY-immunosuppressed mice. When the mice were administered GLA-60 prior to HSV-1 infection, virus growth was inhibited and the mortality rate of infected mice was reduced. Thus, GLA-60 is a potent immunomodulator achieving its antiviral action through enhancement of nonspecific host defense mechanisms. Combined treatment of GLA-60 with the antiviral agent acyclovir (ACV) resulted in greater protection against HSV-1 in the CY-immunosuppressed mice than did single treatment with either GLA-60 or ACV.
AuthorsS Ikeda, T Tominaga, C Nishimura, J Y Homma, M Kiso, A Hasegawa
JournalAntiviral research (Antiviral Res) 1989 May-Jun Vol. 11 Issue 4 Pg. 173-80 ISSN: 0166-3542 [Print] NETHERLANDS
PMID2545164 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiviral Agents
  • Lipid A
  • GLA 60
  • Cyclophosphamide
  • Animals
  • Antiviral Agents (pharmacology)
  • Cyclophosphamide (pharmacology)
  • Female
  • Herpes Simplex (drug therapy)
  • Immunosuppression
  • Killer Cells, Natural (drug effects, immunology)
  • Lipid A (analogs & derivatives, pharmacology, therapeutic use)
  • Macrophages (drug effects, immunology, microbiology)
  • Mice
  • Mice, Inbred Strains
  • Simplexvirus (drug effects, growth & development)

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