Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo.

Abstract

3'-Azido-2,6-diaminopurine-2',3'-dideoxyriboside (AzddDAPR) is a potent and selective inhibitor of human immunodeficiency virus (HIV) replication in vitro. It also inhibits Moloney murine sarcoma virus (MSV)-induced transformation of murine C3H/3T3 embryo fibroblasts. AzddDAPR causes a marked dose-dependent suppression of MSV-induced tumor formation and mortality therewith associated in newborn mice infected with MSV. Combination of AzddDAPR with ribavirin resulted in a marked potentiation of its anti-retrovirus activity in vitro and a significant enhancement of its inhibitory effect on MSV-induced tumor formation in vivo. A slight increase in the in vivo toxicity of AzddDAPR was noted when combined with ribavirin.

• Authors: J Balzarini, P Herdewijn, E De Clercq
• Journal: Antiviral research (Antiviral Res) 1989 May-Jun Vol. 11 Issue 4 Pg. 161-71 ISSN: 0166-3542 [Print] Netherlands
• PMID: 2545163 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Dideoxynucleosides
• Ribonucleosides
• 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside
• Ribavirin
• Dideoxyadenosine

Topics

• Animals
• Antiviral Agents (pharmacology)
• Cell Transformation, Neoplastic
• Cells, Cultured
• Dideoxyadenosine (analogs & derivatives)
• Dideoxynucleosides (pharmacology)
• Drug Synergism
• HIV (drug effects, growth & development)
• Humans
• Mice
• Mice, Inbred Strains
• Moloney murine sarcoma virus (drug effects, genetics, pathogenicity)
• Ribavirin (pharmacology)
• Ribonucleosides (pharmacology)
• Sarcoma Viruses, Murine (drug effects)
• Sarcoma, Experimental (pathology)
• Virus Replication (drug effects)