Novel roles for caspase-8 in IL-1β and inflammasome regulation.

Abstract

Caspase-8 is an initiator and apical activator caspase that plays a central role in apoptosis. Caspase-8-deficient mice are embryonic lethal, which makes study of caspase-8 in primary immune cells difficult. Recent advances have rescued caspase-8-deficient mice by crossing them to mice deficient in receptor-interacting serine-threonine kinase 3 (RIPK3). These genetic tools have made it possible to study the role of caspase-8 in vivo and in primary immune cells. Several recent studies have identified novel roles for caspase-8 in modulating IL-1β and inflammation, showing that caspase-8 directly regulates IL-1β independent of inflammasomes or indirectly through the regulation of inflammasomes, depending on the stimulus or stimuli that initiate the signaling cascade. Here, we address recent findings on caspase-8 and its role in modulating IL-1β and inflammation.

• Authors: Prajwal Gurung, Thirumala-Devi Kanneganti
• Journal: The American journal of pathology (Am J Pathol) Vol. 185 Issue 1 Pg. 17-25 (Jan 2015) ISSN: 1525-2191 [Electronic] United States
• PMID: 25451151 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Chemical References

• Inflammasomes
• Interleukin-1beta
• Receptor-Interacting Protein Serine-Threonine Kinases
• Ripk3 protein, mouse
• CASP8 protein, human
• Casp8 protein, mouse
• Caspase 8

Topics

• Animals
• Autoimmunity
• Caspase 8 (physiology)
• Endoplasmic Reticulum Stress
• Gene Expression Regulation
• HEK293 Cells
• Humans
• Inflammasomes (immunology)
• Inflammation (immunology)
• Interleukin-1beta (physiology)
• Mice
• Mice, Knockout
• Models, Biological
• Protein Structure, Tertiary
• Receptor-Interacting Protein Serine-Threonine Kinases (genetics, metabolism)
• Signal Transduction