Efficacy of albendazole against Taenia multiceps larvae in experimentally infected goats.
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| Abstract |
A controlled trial was conducted to evaluate the efficacy of three therapeutics regimes of albendazole (ABZ) against Taenia multiceps larvae in experimental infected goats. Forty-nine goats experimentally infected with 3000 T. multiceps eggs were selected and randomly divided into treatment or control groups. Treatment with 10mg/kg for 3 days for group 1 (G1), 10mg/kg for group 2 (G2) and 20mg/kg/day for group 3 (G3) was applied 2 months after infection; group 4 (G4) served as a control group. A treatment with doses of 10mg/kg/day for 3 days on group 5 (G5) and group 6 (G6) was used as control, 5 months after the infection. The efficacy of ABZ was assessed as percentage of non-viable cysts which were determined by morphologic characteristics, movement and methyl blue staining technique. The efficacy of ABZ against 2 months old cysts was significantly different from the control and were 90.3% (28/31), 72.7% (8/11) and 73.9% (14/19) for G1, G2 and G3, respectively. No differences were observed in cyst viability between treated and control groups for 5-month old cysts. The results in this study indicate that ABZ is effective in goats against 2-month-old cysts of T. multiceps larva located in tissues outside the brain.
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| Authors | Sónia M S Afonso, Luis Neves, Alberto Pondja, Cristiano Macuamule, Samson Mukaratirwa, Margarita Arboix, Carles Cristòfol, Bettencourt P S Capece |
| Journal | Veterinary parasitology (Vet Parasitol) Vol. 206 Issue 3-4 Pg. 304-7 (Dec 15 2014) ISSN: 1873-2550 [Electronic] Netherlands |
| PMID | 25450723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
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