Abstract | BACKGROUND: METHODS: RESULTS: We found that exposure to isoflurane induces learning and memory deficits of old rats. IL-1β in the hippocampus was increased at 4 h after isoflurane exposure. Isoflurane also increased neuroapoptosis in the hippocampus and decreased neuronal density in the CA1 region. And GTS-21 pretreatment effectively alleviated these changes. CONCLUSIONS:
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Authors | Fei-Juan Kong, Lei-Lei Ma, Hong-Hai Zhang, Jia-Qiang Zhou |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 194
Issue 1
Pg. 255-61
(Mar 2015)
ISSN: 1095-8673 [Electronic] United States |
PMID | 25450597
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Anesthetics, Inhalation
- Benzylidene Compounds
- IL1B protein, rat
- Interleukin-1beta
- Nicotinic Agonists
- Pyridines
- 3-(2,4-dimethoxybenzylidene)anabaseine
- Isoflurane
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Topics |
- Anesthetics, Inhalation
(toxicity)
- Animals
- Apoptosis
(drug effects)
- Benzylidene Compounds
(pharmacology)
- Cognition Disorders
(chemically induced, drug therapy)
- Hippocampus
(chemistry, drug effects)
- Interleukin-1beta
(analysis)
- Isoflurane
(toxicity)
- Male
- Nicotinic Agonists
(pharmacology)
- Pyridines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
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