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Efficacy of icotinib versus traditional chemotherapy as first-line treatment for preventing brain metastasis from advanced lung adenocarcinoma in patients with epidermal growth factor receptor-sensitive mutation.

AbstractOBJECTIVE:
This study aimed to investigate the potential use of icotinib as first-line treatment to prevent brain metastasis from advanced lung adenocarcinoma.
PATIENTS AND METHODS:
This investigation was designed as a retrospective nonrandomized controlled study. Enrolled patients received either icotinib or traditional chemotherapy as their first-line treatment. The therapeutic efficacy was compared among patients with advanced (stages IIIB and IV) lung adenocarcinoma with epidermal growth factor receptor (EGFR)-sensitive mutation. The primary endpoint was the cumulative incidence of brain metastasis, whereas the secondary endpoint was overall survival (OS). Death without brain metastasis was considered a competitive risk to calculate the cumulative risk of brain metastasis. Survival analysis was conducted using the Kaplan-Meier method and statistical significance were determined using the log-rank test.
RESULTS:
The present study included 396 patients with 131 in the icotinib group and 265 in the chemotherapy group. Among those with EGFR-sensitive mutation, the cumulative risk of brain metastasis was lower in the icotinib group than in the chemotherapy group. However, no significant difference in OS was observed between the two groups.
CONCLUSION:
Icotinib can effectively reduce the incidence of brain metastasis and therefore improve prognosis in advanced lung adenocarcinoma patients with EGFR-sensitive mutation.
AuthorsXiao Zhao, Guangqin Zhu, Huoming Chen, Ping Yang, Fang Li, Nan Du
JournalJournal of cancer research and therapeutics (J Cancer Res Ther) Vol. 10 Suppl Pg. C155-9 (Nov 2014) ISSN: 1998-4138 [Electronic] India
PMID25450275 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Antineoplastic Agents
  • Crown Ethers
  • Quinazolines
  • icotinib
  • EGFR protein, human
  • ErbB Receptors
Topics
  • Adenocarcinoma (drug therapy, genetics, pathology)
  • Adenocarcinoma of Lung
  • Aged
  • Antineoplastic Agents (therapeutic use)
  • Brain (pathology)
  • Brain Neoplasms (genetics, pathology, prevention & control)
  • Crown Ethers (therapeutic use)
  • Disease-Free Survival
  • ErbB Receptors (genetics)
  • Female
  • Humans
  • Lung Neoplasms (drug therapy, genetics, pathology)
  • Male
  • Mutation (genetics)
  • Neoplasm Metastasis (genetics, pathology, prevention & control)
  • Neoplasm Staging (methods)
  • Prognosis
  • Quinazolines (therapeutic use)
  • Retrospective Studies
  • Survival Analysis

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