Controversies in neuro-ophthalmology: steroid therapy for traumatic optic neuropathy.

Abstract

BACKGROUND:

There is an increase in the incidence of traumatic optic neuropathy (TON) due to increasing urbanization and rapid spurt in the number of motor vehicles on the road. Despite early presentation and ease of diagnosis the visual outcomes in TON are still limited. There is also significant confusion about the timing, dose and efficacy of steroid treatment in its management.

PURPOSE:

To provide a clinical update of the pros and cons of steroid therapy for TON.

DESIGN:

The paper is a retrospective review of the currently available literature in the English language indexed in PubMed.

METHODS:

A PubMed search was conducted by the authors using the following terms: Traumatic optic neuropathy, megadose, steroids, methylprednisolone. Relevant original articles, review articles, and case reports related to the topic of discussion were evaluated and discussed in the paper.

RESULTS:

There is no prospective randomized control trial evaluating the effect of steroids in TON. There are varying reports on the effect of steroid therapy from significant improvement to no difference compared to observation.

CONCLUSION:

The decision to give steroids to patients with TON has to be on an individual case to case basis and must involve informed consent from the patient. There are documented advantages and disadvantages of steroid therapy and a prospective, randomized, controlled trial is necessary comparing steroids, surgery and observation before definitive management can be evolved.

• Authors: Rohit Saxena, Digvijay Singh, Vimla Menon
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) Vol. 62 Issue 10 Pg. 1028-30 (Oct 2014) ISSN: 1998-3689 [Electronic] India
• PMID: 25449942 (Publication Type: Journal Article, Review)

Chemical References

• Glucocorticoids

Topics

• Glucocorticoids (therapeutic use)
• Humans
• Neurology
• Ophthalmology
• Optic Nerve Injuries (drug therapy)
• Visual Acuity