Colonic diverticulitis in chemotherapy patients: should operative indications change? A retrospective cohort study.

Abstract

INTRODUCTION:

Management of the immunosuppressed patient with diverticular disease remains controversial. We report the largest series of colon cancer patients undergoing chemotherapy and hospitalized for acute diverticulitis, to determine whether recent treatment with systemic chemotherapy is associated with increased risk for/increased severity of recurrent diverticulitis.

METHODS:

Retrospective cohort study of adult patients hospitalized for an initial episode of acute colonic diverticulitis at Memorial Sloan Kettering Cancer Center, 1988-2004. Outcomes in patients receiving systemic chemotherapy within one month of admission for diverticulitis ("Chemo") were compared to outcomes of patients not receiving chemotherapy within the past month ("No-chemo").

RESULTS:

A total 131 patients met inclusion criteria. Chemo patients did not differ significantly from No-chemo group in terms of severity of acute diverticulitis at index admission (13.2% vs. 4.4%, respectively, p = 0.12), resumption of chemotherapy (median 2 months), failure of non-operative management (13.2% vs 4.4%, respectively, p = 0.12), frequency of recurrence (20.5% vs 18.5%), hospital length of stay (p = 0.08), and likelihood of interval resection (24.0% vs. 16.2%, respectively, p = 0.39). Chemo patients recurred with more severe disease, were more likely to undergo emergent surgery (75.0% vs. 23.5%, respectively, p = 0.03), and were more likely to be diverted (100.0% vs. 25.0%, respectively, p = 0.03). Chemo patients were significantly more likely to incur a postoperative complication (100% vs 9.1% p < 0.01) following interval resection. Overall mortality was significantly higher in the Chemo vs. No-chemo group. Median survival in Chemo patients was 3.4 years; in No-chemo patients, median survival was not reached at 10 years.

CONCLUSION:

Our data do not support routine elective surgery for acute diverticulitis in patients receiving chemotherapy. Non-operative management in the acute or interval setting appears preferable whenever possible.

• Authors: Tushar Samdani, Fredric M Pieracci, Soumitra R Eachempati, Jaime Benarroch-Gampel, Alex Weiss, M Cathy Pietanza, Philip S Barie, Garrett M Nash
• Journal: International journal of surgery (London, England) (Int J Surg) Vol. 12 Issue 12 Pg. 1489-94 (Dec 2014) ISSN: 1743-9159 [Electronic] United States
• PMID: 25448673 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents

Topics

• Acute Disease
• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents (therapeutic use)
• Cohort Studies
• Colonic Neoplasms (complications, drug therapy, immunology)
• Diverticulitis, Colonic (complications, surgery)
• Elective Surgical Procedures
• Female
• Humans
• Immunocompromised Host
• Male
• Middle Aged
• Recurrence
• Retrospective Studies