HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Role of posterior hypothalamus in hypobaric hypoxia induced pulmonary edema.

Abstract
To investigate the role of posterior hypothalamus and central neurotransmitters in the pulmonary edema due to hypobaric hypoxia, rats were placed in a high altitude simulation chamber (barometric pressure-294.4 mmHg) for 24 h. Exposure to hypobaric hypoxia resulted in increases in mean arterial blood pressure, renal sympathetic nerve activity, right ventricular systolic pressure, lung wet to dry weight ratio and Evans blue dye leakage. There was a significant attenuation in these responses to hypobaric hypoxia (a) after lesioning posterior hypothalamus and (b) after chronic infusion of GABAA receptor agonist muscimol into posterior hypothalamus. No such attenuation was evident with the chronic infusion of the nitric oxide donor SNAP into the posterior hypothalamus. It is concluded that in hypobaric hypoxia, there is over-activity of posterior hypothalamic neurons probably due to a local decrease in GABA-ergic inhibition which increases the sympathetic drive causing pulmonary hypertension and edema.
AuthorsR K Sharma, R C Choudhary, M K Reddy, A Ray, K Ravi
JournalRespiratory physiology & neurobiology (Respir Physiol Neurobiol) Vol. 205 Pg. 66-76 (Jan 01 2015) ISSN: 1878-1519 [Electronic] Netherlands
PMID25448396 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • GABA-A Receptor Agonists
  • Nitric Oxide Donors
  • Muscimol
  • S-Nitroso-N-Acetylpenicillamine
Topics
  • Altitude Sickness (physiopathology)
  • Animals
  • Disease Models, Animal
  • GABA-A Receptor Agonists (pharmacology)
  • Hypertension, Pulmonary (physiopathology)
  • Hypothalamus, Posterior (drug effects, physiopathology)
  • Hypoxia (physiopathology)
  • Male
  • Muscimol (pharmacology)
  • Nitric Oxide Donors (pharmacology)
  • Pulmonary Edema (physiopathology)
  • Rats
  • Rats, Wistar
  • S-Nitroso-N-Acetylpenicillamine (pharmacology)
  • Sympathetic Nervous System (drug effects, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: