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The kallikrein system in retinal damage/protection.

Abstract
Kallikrein is a serine protease involved in the kallikrein-kinnin system. Kallikrein is derived from the blood plasma or tissue, and is correlated with aggravation and improvement in eye diseases, such as, glaucoma, diabetic retinopathy, age-related macular degeneration, and ocular ischemic syndrome. The plasma kallikrein stimulates retinal vascular permeability and intraocular hemorrhage. On the other hand, we had reported that the tissue kallikrein normalizes retinal vasopermeability and inhibited retinal neovascularization and retinal ischemic injury. The protective mechanisms of the tissue-derived kallikrein include the cleavage of vascular endothelial growth factor (VEGF), which suggests that the tissue kallikrein could be potentially-effective against any disease involving the VEGF production.
AuthorsTomomi Masuda, Masamitsu Shimazawa, Hideaki Hara
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 749 Pg. 161-3 (Feb 15 2015) ISSN: 1879-0712 [Electronic] Netherlands
PMID25448306 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Vascular Endothelial Growth Factor A
  • Kallikreins
Topics
  • Animals
  • Humans
  • Kallikreins (blood, metabolism)
  • Retinal Diseases (metabolism)
  • Vascular Endothelial Growth Factor A (metabolism)

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