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Hepatitis C virus (HCV) reactivation caused by steroid therapy for dermatomyositis.

Abstract
A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis. On admission, her serum was positive for anti-hepatitis C virus (HCV) antibodies, although HCV RNA was undetectable on polymerase chain reaction. Glucocorticoid therapy improved the dermatomyositis; however, the serum alanine aminotransferase levels rapidly increased, with positive serum HCV RNA and a high viral titer. Both parameters decreased in association with prednisolone tapering, whereas dermatomyositis subsequently recurred and the administration of glucocorticoid therapy was repeated. The serum alanine aminotransferase and HCV RNA levels subsequently increased in a similar manner to that observed after the first course of therapy. Liver enzymes and the viral load should be monitored in anti-HCV-positive patients receiving immunosuppressives, even if serum HCV RNA is negative.
AuthorsNami Mori, Michio Imamura, Shintaro Takaki, Takehisa Araki, Nelson C Hayes, Yasuyuki Aisaka, Kazuaki Chayama
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 53 Issue 23 Pg. 2689-93 ( 2014) ISSN: 1349-7235 [Electronic] Japan
PMID25447651 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Hepatitis C Antibodies
  • RNA, Viral
  • Prednisolone
  • Alanine Transaminase
Topics
  • Aged
  • Alanine Transaminase (blood)
  • Anti-Inflammatory Agents (administration & dosage, adverse effects)
  • Dermatomyositis (drug therapy)
  • Female
  • Hepacivirus (genetics, immunology, isolation & purification)
  • Hepatitis C (diagnosis, genetics, immunology)
  • Hepatitis C Antibodies (blood)
  • Humans
  • Polymerase Chain Reaction
  • Prednisolone (administration & dosage, adverse effects)
  • RNA, Viral (blood)
  • Treatment Outcome
  • Virus Activation
  • Virus Latency

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