The 3'UTR 1188A/C polymorphism of IL-12p40 is not associated with susceptibility for developing plaque psoriasis in Mestizo population from western Mexico.

Abstract

Psoriasis is a chronic autoimmune inflammatory disease that affects the skin and the joints. Psoriasis is characterized by the keratinocyte proliferation, which is induced by cytokines Th1 and Th17. Patients with plaque psoriasis present a chronic inflammatory response with high levels of interleukin (IL)-12 and IL-23. Various single-nucleotide polymorphisms (SNP) have been identified in the IL12B gene, such as SNP 3' UTR 1188 A/C (SNP rs3212227), which has been associated with susceptibility to developing plaque psoriasis and with the production of IL-12 and IL-23 in individuals of different ethnic groups. In this study, we determined whether there is an association of SNP rs3212227 with the susceptibility of developing plaque psoriasis and with serum levels of IL-12 and IL-23 in Mestizo population in western Mexico. We included 112 patients with psoriasis and 112 clinical healthy individuals in the study. The frequencies of genotypes A/A, A/C, and C/C in patients with plaque psoriasis were 41, 53, and 6%, respectively, while in the control group, these were 37, 53, and 10%, respectively, without finding statistically significant differences between both groups (p>0.05). Although IL-12 and IL-23 serum levels were higher in patients than in controls, we found no significant differences. The group of patients with genotype CC presented the highest levels of IL-23 (p<0.05). These data suggest that the SNP rs3212227 phenotype is not associated with the risk of developing plaque psoriasis or with IL-12 and IL-23 levels in Mestizo population in western Mexico.

• Authors: Ana Karen Sandoval-Talamantes, Myrian Johanna Brito-Luna, Mary Fafutis-Morris, Delfina Guadalupe Villanueva-Quintero, Omar Graciano-Machuca, María Guadalupe Ramírez-Dueñas, Anabell Alvarado-Navarro
• Journal: Immunology letters (Immunol Lett) Vol. 163 Issue 2 Pg. 221-6 (Feb 2015) ISSN: 1879-0542 [Electronic] Netherlands
• PMID: 25447399 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

Chemical References

• 3' Untranslated Regions
• Interleukin-12 Subunit p40
• Interleukin-23
• Interleukin-12

Topics

• 3' Untranslated Regions (genetics)
• Adult
• Alleles
• Analysis of Variance
• Case-Control Studies
• Ethnicity (genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Interleukin-12 (blood)
• Interleukin-12 Subunit p40 (genetics)
• Interleukin-23 (blood)
• Male
• Mexico
• Middle Aged
• Odds Ratio
• Polymorphism, Single Nucleotide
• Psoriasis (blood, genetics)
• Risk Factors