Abstract | OBJECTIVE: METHODS: Following 17min of untreated VF, 20 pigs were randomized to Control treatment with active compression/ decompression (ACD) CPR and impedance threshold device (ITD) (n=8) or Bundle therapy with stutter ACD CPR+ITD+ sevoflurane+P188 (n=12). Epinephrine and post- resuscitation hypothermia were given in both groups per standard protocol. Animals that achieved return of spontaneous circulation (ROSC) were evaluated with echocardiography, biomarkers, and a blinded neurologic assessment with a cerebral performance category score. RESULTS: Bundle therapy improved hemodynamics during resuscitation, reduced need for epinephrine and repeated defibrillation, reduced biomarkers of cardiac injury and end-organ dysfunction, and increased left ventricular ejection fraction compared to Controls. Bundle therapy also improved rates of ROSC (100% vs. 50%), freedom from major adverse events (50% vs. 0% at 48h), and neurologic function (42% with mild or no neurologic deficit and 17% achieving normal function at 48h). CONCLUSIONS: Bundle therapy with a combination of stutter ACD CPR, ITD, sevoflurane, and P188 improved cardiac and neurologic function after 17min of untreated cardiac arrest in pigs. All studies were performed with approval from the Institutional Animal Care Committee of the Minneapolis Medical Research Foundation (protocol #12-11).
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Authors | Jason A Bartos, Timothy R Matsuura, Mohammad Sarraf, Scott T Youngquist, Scott H McKnite, Jennifer N Rees, Daniel T Sloper, Frank S Bates, Nicolas Segal, Guillaume Debaty, Keith G Lurie, Robert W Neumar, Joseph M Metzger, Matthias L Riess, Demetris Yannopoulos |
Journal | Resuscitation
(Resuscitation)
Vol. 87
Pg. 7-13
(Feb 2015)
ISSN: 1873-1570 [Electronic] Ireland |
PMID | 25447036
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Anesthetics, Inhalation
- Methyl Ethers
- Sevoflurane
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Topics |
- Anesthetics, Inhalation
(pharmacology)
- Animals
- Cardiopulmonary Resuscitation
(adverse effects, methods)
- Coronary Circulation
- Disease Models, Animal
- Female
- Heart
(physiopathology)
- Heart Arrest
(etiology, therapy)
- Hemodynamics
- Humans
- Ischemic Postconditioning
(methods)
- Male
- Methyl Ethers
(pharmacology)
- Myocardial Reperfusion Injury
(prevention & control)
- Neurologic Examination
- Sevoflurane
- Stroke Volume
- Swine
- Time Factors
- Treatment Outcome
- Ventricular Fibrillation
(complications)
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