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The effects of D-allose on transient ischemic neuronal death and analysis of its mechanism.

Abstract
The present study investigates the neuroprotective effects of d-allose, a rare sugar, against ischemia/reperfusion injury in a gerbil model. Transient forebrain ischemia was induced by occlusion of the bilateral common carotid arteries for 5 min. D-Allose was intravenously injected before and after ischemia (200 mg/kg). Extracellular glutamate and lactate release from the gerbil brain, and PO₂ profiles were monitored during ischemia and reperfusion. We also examined neuronal death and oxidative damage in the hippocampus one week after ischemia reperfusion, and investigated functional outcome. D-Allose administration suppressed glutamate and lactate release compared to vehicle controls. Brain damage, 8-OHdG levels (a marker of oxidative stress) and locomotor activities were significantly decreased by D-allose treatment. The present results suggest that d-allose reduces delayed neuronal death and behavioral deficits after transient ischemia by changing cerebral metabolism and inhibiting oxidative stress.
AuthorsYanan Liu, Takehiro Nakamura, Tetsuhiko Toyoshima, Aya Shinomiya, Takashi Tamiya, Masaaki Tokuda, Richard F Keep, Toshifumi Itano
JournalBrain research bulletin (Brain Res Bull) Vol. 109 Pg. 127-31 (Oct 2014) ISSN: 1873-2747 [Electronic] United States
PMID25445611 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Lactic Acid
  • Glutamic Acid
  • allose
  • 8-Hydroxy-2'-Deoxyguanosine
  • Deoxyguanosine
  • Glucose
  • Oxygen
Topics
  • 8-Hydroxy-2'-Deoxyguanosine
  • Analysis of Variance
  • Animals
  • Cerebral Cortex (drug effects, metabolism, pathology)
  • DNA Damage (drug effects)
  • Deoxyguanosine (analogs & derivatives)
  • Disease Models, Animal
  • Drug Administration Schedule
  • Gerbillinae
  • Glucose (pharmacology, therapeutic use)
  • Glutamic Acid (metabolism)
  • Ischemic Attack, Transient (complications, drug therapy, pathology)
  • Lactic Acid (metabolism)
  • Male
  • Microdialysis
  • Movement Disorders (etiology)
  • Neurons (drug effects)
  • Oxygen (metabolism)
  • Time Factors

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