Choreito formula for BK virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.

Abstract

Therapy for BK virus (BKV)-associated hemorrhagic cystitis (BKV-HC) is limited after hematopoietic stem cell transplantation (HSCT). We examined whether choreito, a formula from Japanese traditional Kampo medicine, is effective for treating BKV-HC. Among children who underwent allogeneic HSCT between October 2006 and March 2014, 14 were diagnosed with BKV-HC (median, 36 days; range, 14 to 330 days) after HSCT, and 6 consecutive children received pharmaceutical-grade choreito extract granules. The hematuria grade before treatment was significantly higher in the choreito group than in the nonchoreito group (P = .018). The duration from therapy to complete resolution was significantly shorter in the choreito group (median, 9 days; range, 4 to 17 days) than in the nonchoreito group (median, 17 days; range, 15 to 66 days; P = .037). In 11 children with macroscopic hematuria, the duration from treatment to resolution of macroscopic hematuria was significantly shorter in the choreito group than in the nonchoreito group (median, 2 days versus 11 days; P = .0043). The BKV load in urine was significantly decreased 1 month after choreito administration. No adverse effects related to choreito administration were observed. Choreito may be a safe and considerably promising therapy for the hemostasis of BKV-HC after HSCT.

• Authors: Nozomu Kawashima, Yoshinori Ito, Yuko Sekiya, Atsushi Narita, Yusuke Okuno, Hideki Muramatsu, Masahiro Irie, Asahito Hama, Yoshiyuki Takahashi, Seiji Kojima
• Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (Biol Blood Marrow Transplant) Vol. 21 Issue 2 Pg. 319-25 (Feb 2015) ISSN: 1523-6536 [Electronic] United States
• PMID: 25445026 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Chemical References

• Antiviral Agents
• DNA, Viral
• Drugs, Chinese Herbal
• choreito

Topics

• Adolescent
• Antiviral Agents (therapeutic use)
• BK Virus (drug effects, immunology)
• Child
• Cystitis (drug therapy, immunology, pathology, virology)
• DNA, Viral (antagonists & inhibitors, urine)
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Hematologic Neoplasms (immunology, pathology, therapy, virology)
• Hematopoietic Stem Cell Transplantation
• Hematuria (drug therapy, immunology, pathology, virology)
• Humans
• Japan
• Male
• Medicine, East Asian Traditional
• Retrospective Studies
• Time Factors
• Transplantation, Homologous
• Treatment Outcome
• Tumor Virus Infections (drug therapy, immunology, pathology, virology)
• Viral Load (drug effects)
• Viremia (drug therapy, immunology, pathology, virology)