Abstract | OBJECTIVES: METHODS: Prospective cohort study. We included all adults with solid or hematologic cancer receiving active chemotherapy treatment during the winter of 2010-2011 in a cancer center. We compared baseline characteristics and outcomes between patients with and without chemotherapy delays, cancellations, or dose-reductions (" chemotherapy delay"). RESULTS: We included 547 patients receiving chemotherapy during the winter of 2011. Of these, 213 (38.9%) patients experienced 306 episodes of chemotherapy delays. The main documented reasons for the chemotherapy delay were neutropenia (84/306, 27.4%), fever or infection (73/306, 23.9%) and thrombocytopenia (26/306, 8.5%). Independent risk factors for chemotherapy delays were upper respiratory infections (OR 1.87, 95% CI 1.27-2.76), lymphopenia, prior hospitalization, peripheral vascular disease and colon cancer relative to hematologic cancer. In the adjusted analysis focusing on chemotherapy delays due to infection alone, upper respiratory infections (OR 5.25, 95% I 2.81-9.84) and age were significant independent risk factors. DISCUSSION:
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Authors | Ahmed Taha, Inbal Vinograd, Ali Sakhnini, Noa Eliakim-Raz, Laura Farbman, Rina Baslo, Salomon M Stemmer, Anat Gafter-Gvili, Leonard Leibovici, Mical Paul |
Journal | The Journal of infection
(J Infect)
Vol. 70
Issue 3
Pg. 223-9
(Mar 2015)
ISSN: 1532-2742 [Electronic] England |
PMID | 25444974
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Age Factors
- Aged
- Antineoplastic Agents
(therapeutic use)
- Cohort Studies
- Female
- Fever
- Hematologic Neoplasms
(complications, drug therapy)
- Humans
- Influenza, Human
(complications)
- Lymphopenia
- Male
- Medication Adherence
- Middle Aged
- Neoplasms
(complications, drug therapy)
- Neutropenia
- Prospective Studies
- Respiratory Tract Infections
(virology)
- Risk Factors
- Surveys and Questionnaires
- Thrombocytopenia
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