[Oncogenes in human gastric carcinoma].

Abstract

Alteration of oncogene and loss of chromosomal heterozygosity are infrequent in human gastric carcinoma compared with those in other gastrointestinal carcinomas. Amplification of c-erbB-2 gene is observed in well differentiated adenocarcinoma, while sam gene is found in poorly differentiated adenocarcinoma or scirrhous carcinoma. sam gene, which was isolated from a gastric cancer cell line KATO-III by a DNA renaturation method, encodes tyrosine-specific protein kinase domain. A good correlation evidently exists between the synchronous expression of TGF alpha and ras p21 and biological malignancy of gastric carcinoma. c-myc and c-fos proteins are found not only in tumor cells but also in stromal cells including macrophages and fibroblast around the tumors. The prognosis of patients with c-myc p 62-positive stromal cells is significantly better than that of patient with p 62-negative stromal cells. Coamplification of the hst-1 gene and int-2 is observed in 50% of primary tumors and all metastatic tumors of esophageal carcinoma. PCR (polymerase chain reaction) technique seems to be useful for the detection of oncogene point mutation in human gastric carcinoma.

• Authors: E Tahara
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 6 Pg. 2149-55 (Jun 1989) ISSN: 0385-0684 [Print] Japan
• PMID: 2544146 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Proto-Oncogene Proteins
• Proto-Oncogene Proteins c-fos
• Proto-Oncogene Proteins c-myc
• Fibroblast Growth Factors
• Transforming Growth Factors
• HRAS protein, human
• Proto-Oncogene Proteins p21(ras)

Topics

• Adenocarcinoma (analysis, genetics, pathology)
• Adenocarcinoma, Scirrhous (analysis, genetics, pathology)
• Esophageal Neoplasms (genetics, pathology)
• Fibroblast Growth Factors (genetics)
• Gene Amplification
• Genes, ras
• Humans
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Oncogenes
• Proto-Oncogene Proteins (analysis)
• Proto-Oncogene Proteins c-fos
• Proto-Oncogene Proteins c-myc
• Proto-Oncogene Proteins p21(ras)
• Stomach Neoplasms (analysis, genetics, pathology)
• Transforming Growth Factors (analysis)