Intratubular hemoglobin casts in hemolysis-associated acute kidney injury.

Abstract

Kidney injury is a complication of intravascular hemolysis associated with many forms of hemolytic disease. Reports of kidney biopsy findings in patients with hemolysis-related kidney injury have focused primarily on the accumulation of hemosiderin pigment within proximal tubular epithelial cells (hemosiderosis), a feature of chronic hemolysis. The nephrotoxic effects of hemoglobin include direct cytotoxicity to tubular cells, but hemoglobin also can precipitate in distal nephron segments, forming obstructive casts. We present a case of hemolysis-associated tubular injury, characterized by acute onset of intravascular hemolysis followed by acute kidney injury with acute tubular injury and abundant intratubular casts containing hemoglobin.

• Authors: Mazdak A Khalighi, Kammi J Henriksen, Anthony Chang, Shane M Meehan
• Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis) Vol. 65 Issue 2 Pg. 337-41 (Feb 2015) ISSN: 1523-6838 [Electronic] United States
• PMID: 25441434 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Hemoglobins

Topics

• Acute Kidney Injury (blood, diagnosis)
• Adult
• Female
• Hemoglobins (metabolism)
• Hemolysis (physiology)
• Humans
• Kidney Tubules (metabolism, pathology)