Abstract | PURPOSE: METHODS: FINDINGS: Among the patients taking NOACs, those taking dabigatran had the highest total QALYs (7.68 QALYs), followed by apixaban (7.63 QALYs) and rivaroxaban (7.47 QALYs). Patients taking dabigatran had the lowest total lifetime costs (£23,342), followed by apixaban (£24,014) and rivaroxaban (£25,220). The differences between dabigatran and apixaban were modest but consistent in sensitivity analyses, with the directionality only changing at the limits of the CIs for the relative risks of ischemic stroke or intracranial hemorrhage or when assuming that both treatment discontinuation and post-event disability rates differ by drug. IMPLICATIONS:
Dabigatran was found to be economically dominant over rivaroxaban and apixaban in the UK setting. These economic findings are based on relative clinical efficacy from an indirect treatment comparison and would benefit from any data of direct comparisons of the NOACs in the future.
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Authors | Ying Zheng, Sonja V Sorensen, Ann-Katrin Gonschior, Herbert Noack, Jutta Heinrich-Nols, Tom Sunderland, Anuraag R Kansal |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 36
Issue 12
Pg. 2015-2028.e2
(Dec 01 2014)
ISSN: 1879-114X [Electronic] United States |
PMID | 25438722
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anticoagulants
- Pyrazoles
- Pyridones
- apixaban
- Warfarin
- Rivaroxaban
- Dabigatran
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Topics |
- Anticoagulants
(economics, therapeutic use)
- Atrial Fibrillation
(drug therapy, economics)
- Cost-Benefit Analysis
- Dabigatran
(economics, therapeutic use)
- Embolism
(economics, prevention & control)
- Hemorrhage
(chemically induced)
- Humans
- Models, Theoretical
- Pyrazoles
(economics, therapeutic use)
- Pyridones
(economics, therapeutic use)
- Quality-Adjusted Life Years
- Rivaroxaban
(economics, therapeutic use)
- Stroke
(economics, prevention & control)
- United Kingdom
- Warfarin
(therapeutic use)
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