Study on the anti-depressant effect of Chaihu Guizhi decoction and its mechinisims of actions.

Abstract

BACKGROUND:

Chaihu Guizhi has the effects of treating exogenous wind-cold; alternating episodes of chills and fever; noisy nose and retching; strong headache; chest and rib-side pain, and fullness, in clinical practice, it can also be used for the treatment of depression. The objective of this paper was to study the anti-depressant effect of Chaihu Guizhi decoction and its mechanism.

MATERIALS AND METHODS:

The anti-depressant effect of Chaihu Guizhi decoction was investigated by forced swimming test, tail suspension test and antagonism of reserpine hypothermia test in mice.

RESULTS:

Chaihu Guizhi decoction could significantly shorten immobility time of mice in the forced swimming test, and dose-dependence significantly shorten immobility time of mice in the tail suspension test, after administration of 50, 100, and 200mg/kg, Chaihu Guizhi decoction, a significant dose-dependent antagonism of reserpine-induced hypothermia was observed in mice of each treatment group.

CONCLUSION:

Chaihu Guizhi decoction has an antidepressant effect.

• Authors: Yu Liu, Chunmei Cao, Haijun Ding
• Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM (Afr J Tradit Complement Altern Med) Vol. 11 Issue 2 Pg. 273-6 ( 2014) ISSN: 2505-0044 [Electronic] Nigeria
• PMID: 25435607 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidepressive Agents
• Drugs, Chinese Herbal

Topics

• Animals
• Antidepressive Agents (administration & dosage)
• Depression (drug therapy, physiopathology)
• Disease Models, Animal
• Drugs, Chinese Herbal (administration & dosage)
• Hindlimb Suspension
• Humans
• Male
• Mice
• Swimming