Preventing effect of "liuwei dihuang decoction" on esophageal carcinoma.

Abstract

Liuwei Dihuang Decoction is a representative classic prescription for nourishing Yin in Traditional Chinese Medicine. Experimental and clinical studies showed that the recipe could 1. inhibit carcinogenesis of anterior stomach by N-nitrososarcosine ethyl ester in mice; 2. inhibit the formation of lung tumors induced by Urethan in mice; 3. decrease spontaneous tumorigenesis in LACA strain; 4. inhibit the mutagenic activity of Endoxan in micronuclear test. Patients with epithelial dysplasia of esophagus, a preneoplastic lesion, were treated by using this recipe. The canceration rate within 1 year was 2.2% in the treated and 12.4% in an untreated group. Within 5 years these rates were 9% and 26% respectively (p less than 0.025).

• Authors: T L Jiang, S C Yan, L F Zhao
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 4 Pt 2-2 Pg. 1511-8 (Apr 1989) ISSN: 0385-0684 [Print] Japan
• PMID: 2543308 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Nitrosamines
• N-nitrososarcosine ethyl ester
• Urethane
• Cyclophosphamide
• Cyclic AMP

Topics

• Animals
• Cell Nucleus (drug effects, pathology)
• Cyclic AMP (biosynthesis)
• Cyclophosphamide (antagonists & inhibitors, toxicity)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Epithelium (drug effects, pathology)
• Esophageal Neoplasms (drug therapy, pathology, prevention & control)
• Female
• Humans
• Hyperplasia
• Lung Neoplasms (chemically induced, prevention & control)
• Mice
• Mutagenicity Tests
• Mutation
• Neoplasms, Experimental (chemically induced, immunology, pathology)
• Nitrosamines
• Phagocytosis (drug effects)
• Precancerous Conditions (drug therapy, pathology)
• Spleen (drug effects, pathology)
• Stomach Neoplasms (chemically induced, prevention & control)
• Thyroid Gland (drug effects, physiopathology)
• Urethane
• Uterine Cervical Neoplasms (drug therapy, metabolism, mortality)