Ultrastructure of hepatorenal cell populations in patients with HCV and HBV infection markers. Hepatorenal associations.

Abstract

Hepatorenal cell populations were studied in patients with HCV and HBV infection markers and renal dysfunction. Pronounced mosaicism of ultrastructural changes in hepatocytes was associated with polymorphic cytopathic effects caused by RNA-genome hepatitis C virus and DNA-genome hepatitis B virus. The destructive component of the tubular compartment predominated in renal biopsy specimens from patients, with subsequent degeneration of the tubular epithelium associated with progressive interstitial fi brosis. Immunohistochemical studies detected HCV NS3Ag and HBcAg structural marker in the tubular epitheliocytes. An appreciable part of the structural and functional changes in the liver in patients with HCV and HBV infections was caused by the therapeutic complex, including programmed hemoperfusion.

• Authors: G I Nepomnyashchikh, M A Bakarev, D L Nepomnyashchikh, A V Yudanov, V I Kapustina, O A Postnikova, E V Vinogradova, S G Rusinova, T A Telegina
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 158 Issue 2 Pg. 268-73 (Dec 2014) ISSN: 1573-8221 [Electronic] United States
• PMID: 25430651 (Publication Type: Journal Article)

Chemical References

• Biomarkers

Topics

• Adolescent
• Adult
• Biomarkers (metabolism)
• Female
• Hepatitis B (metabolism)
• Hepatitis C (metabolism)
• Hepatocytes (ultrastructure)
• Hepatorenal Syndrome (pathology)
• Humans
• Immunohistochemistry
• Kidney (ultrastructure)
• Male
• Microscopy, Electron
• Middle Aged