Abstract | INTRODUCTION: OBJECTIVE: STUDY DESIGN AND SETTING: This study used a prospective general population cohort design and was based on data from the Swedish Good Aging in Skåne study (GÅS-SNAC), they were studied 6 years after baseline of the present study, with the same study protocol at baseline and at follow-up. The study sample comprised 1,480 randomly invited subjects aged 60 to 93 years, and had a participation rate of 82% at follow-up. OH test included assessment of blood pressure and symptoms of OH. RESULTS: The 6-year incidence of MCI was 8%, increasing from 12.1 to 40.5 per 1,000 person-years for men and 6.9 to 16.9 per 1,000 person-years for women aged 60 to >80 years. The corresponding 6-year incidence of dementia was 8%. Orthostatic intolerance during uprising was related to risk for MCI at follow-up (odds ratio [OR] =1.84 [1.20-2.80][95% CI]), adjusted for age and education independently of blood pressure during testing. After stratification for hypertension (HT), the corresponding age-adjusted OR for MCI in the non-HT group was 1.71 (1.10-2.31) and 1.76 (1.11-2.13) in the HT group. Among controls, the proportion of those with OH was 16%; those with MCI 24%; and those with dementia 31% (age-adjusted OR 1.93 [1.19-3.14]). CONCLUSION: Not only OH, but also symptoms of OH, seem to be a risk factor for cognitive decline and should be considered in the management of blood pressure among the elderly population.
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Authors | Sölve Elmståhl, Elisabet Widerström |
Journal | Clinical interventions in aging
(Clin Interv Aging)
Vol. 9
Pg. 1993-2002
( 2014)
ISSN: 1178-1998 [Electronic] New Zealand |
PMID | 25429211
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Age Factors
- Aged
- Aged, 80 and over
- Aging
(physiology)
- Blood Pressure
- Cognitive Dysfunction
(epidemiology)
- Dementia
(epidemiology)
- Female
- Health Behavior
- Humans
- Hypotension, Orthostatic
(epidemiology)
- Incidence
- Male
- Middle Aged
- Neuropsychological Tests
- Orthostatic Intolerance
(epidemiology)
- Prevalence
- Prospective Studies
- Risk Factors
- Sex Factors
- Sweden
(epidemiology)
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