Abstract | BACKGROUND: OBJECTIVE: We aim to evaluate the potential activity of starting hypothalamic-pituitary-testicular (HPT) axis of male rats with delayed puberty. MATERIALS AND METHODS: RESULTS: Soy isoflavones could significantly decrease body weight, body length, testicular organ coefficient T in serum, GnRH in hypothalamus, FSH and LH in pituitary gland. Both of EXD and TU could improve the condition. E2 and LH in serum of all groups were non-significance of difference (P > 0.05). The immunohistochemical results were well consistent with LH in pituitary gland. CONCLUSION: The results of the present research indicate that EXD extract is effective to start the HPT axis in puberty and can significantly improve sexual developmental inhibition caused by soy isoflavones.
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Authors | Zheng Zhu, LiHong Li, Xin Jin, JianWei Fang, DongFang Zhang |
Journal | Pharmacognosy magazine
(Pharmacogn Mag)
Vol. 10
Issue 40
Pg. 517-21
(Oct 2014)
ISSN: 0973-1296 [Print] India |
PMID | 25422555
(Publication Type: Journal Article)
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