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Small cell lung cancer and progressive retinopathy.

Abstract
Cancer-associated retinopathy (CAR) is one of the paraneoplastic neurological syndromes and characterised by retinal degeneration. Autoimmunity between cancer cells and retinal proteins is considered a major cause of CAR. The presence of serum autoantibodies to retinal antigens plays an important role in the diagnosis. A 60-year-old man reporting of visual disturbance and paresthaesia of extremities presented to our hospital. CT scan revealed a massive tumour in the left lower lobe of the lung. Small cell lung cancer was diagnosed histologically with bronchoscopy. Ophthalmological examination showed retinopathy but not optic neuritis. Anti-CV2/collapsin response mediator protein (CRMP)-5 and anti-Hu antibodies were detected by further serum examination. It has been reported that anti-CV2/CRMP5 antibodies are present in patients with neoplasms accompanied by retinopathy as well as optic neuritis. This is the first case of CAR with presence of anti-CV2/CRMP5 antibodies without neuritis.
AuthorsMami Morita, Tatsuro Fukuhara, Hidetoshi Takahashi, Makoto Maemondo
JournalBMJ case reports (BMJ Case Rep) Vol. 2014 (Nov 24 2014) ISSN: 1757-790X [Electronic] England
PMID25422332 (Publication Type: Case Reports, Journal Article)
Copyright2014 BMJ Publishing Group Ltd.
Chemical References
  • Autoantibodies
  • ELAV Proteins
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • DPYSL5 protein, human
  • Hydrolases
Topics
  • Autoantibodies (blood)
  • ELAV Proteins (immunology)
  • Electroretinography
  • Humans
  • Hydrolases
  • Lung Neoplasms (complications)
  • Male
  • Microtubule-Associated Proteins
  • Middle Aged
  • Nerve Tissue Proteins (immunology)
  • Paraneoplastic Syndromes, Ocular (diagnosis)
  • Retinal Degeneration (complications, diagnosis)
  • Small Cell Lung Carcinoma (complications)

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