The effect of sequential therapy with lansoprazole and ecabet sodium in treating iatrogenic gastric ulcer after endoscopic submucosal dissection: a randomized prospective study.

Abstract

OBJECTIVE:

Ecabet sodium (ES) is a new non-systemic anti-ulcer agent belonging to the category of gastroprotective agents. In this study we aimed to compare the efficacy of a combination therapy with lansoprazole (LS) followed by ES with LS alone in treating endoscopic submucosal dissection (ESD)-induced iatrogenic gastric ulcers.

METHODS:

Patients diagnosed with gastric adenomas or early gastric cancer were randomly divided into either the LS group (30 mg once daily for 4 weeks; n = 45) or the LS + ES group (LS 30 mg once daily for one week followed by ES 1500 mg twice daily for 3 weeks; n = 45). Four weeks after ESD, a follow-up endoscopy was conducted to evaluate the proportions of ulcer reduction and ulcer stages in the two groups.

RESULTS:

In all, 79 patients were included in the final analyses. Both treatment modalities were well-tolerated in most patients, with a drug compliance of over 80%. There were no significant differences between the two groups in terms of the proportions of ulcer reduction (0.9503 ± 0.1215 in the LS group vs 0.9192 ± 0.0700 in the LS + ES group, P = 0.169) or ulcer stage (P = 0.446). The prevalence of adverse events related to drugs and bleeding were also similar between the two groups.

CONCLUSION:

Sequential therapy with LS + ES is as effective as LS alone against ESD-induced gastric ulcers.

• Authors: Ji Yong Ahn, Chang Hwan Choi, Jang Wook Lee, Sung Jin Park, Jeong Wook Kim, Sae Kyung Chang, Seung Bong Han
• Journal: Journal of digestive diseases (J Dig Dis) Vol. 16 Issue 2 Pg. 75-82 (Feb 2015) ISSN: 1751-2980 [Electronic] Australia
• PMID: 25420889 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

Chemical References

• Abietanes
• Anti-Ulcer Agents
• Lansoprazole
• ecabet

Topics

• Abietanes (administration & dosage)
• Aged
• Anti-Ulcer Agents (administration & dosage)
• Dissection (adverse effects)
• Drug Therapy, Combination
• Endoscopy, Gastrointestinal (methods)
• Female
• Gastric Mucosa (surgery)
• Humans
• Iatrogenic Disease
• Lansoprazole (administration & dosage)
• Male
• Middle Aged
• Prospective Studies
• Random Allocation
• Stomach Neoplasms (surgery)
• Stomach Ulcer (drug therapy, etiology)