Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines.

Abstract

We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs(10,11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory phenomenon, rather than a structural defect, as proven by the ability to rescue expression of HLA-A11 in in vitro Epstein-Barr virus (EBV)-converted sublines of EBV negative BLs.

• Authors: M G Masucci, N J Stam, S Torsteinsdottir, J J Neefjes, G Klein, H L Ploegh
• Journal: Cellular immunology (Cell Immunol) Vol. 120 Issue 2 Pg. 396-400 (May 1989) ISSN: 0008-8749 [Print] Netherlands
• PMID: 2541930 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Histocompatibility Antigens Class I

Topics

• Alleles
• Burkitt Lymphoma (immunology)
• Genes, MHC Class I
• Herpesvirus 4, Human
• Histocompatibility Antigens Class I (analysis)
• Humans
• Tumor Cells, Cultured