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At the centre: influenza A virus ribonucleoproteins.

Abstract
Influenza A viral ribonucleoprotein (vRNP) complexes comprise the eight genomic negative-sense RNAs, each of which is bound to multiple copies of the vRNP and a trimeric viral polymerase complex. The influenza virus life cycle centres on the vRNPs, which in turn rely on host cellular processes to carry out functions that are necessary for the successful completion of the virus life cycle. In this Review, we discuss our current knowledge about vRNP trafficking within host cells and the function of these complexes in the context of the virus life cycle, highlighting how structure contributes to function and the crucial interactions with host cell pathways, as well as on the information gaps that remain. An improved understanding of how vRNPs use host cell pathways is essential to identify mechanisms of virus pathogenicity, host adaptation and, ultimately, new targets for antiviral intervention.
AuthorsAmie J Eisfeld, Gabriele Neumann, Yoshihiro Kawaoka
JournalNature reviews. Microbiology (Nat Rev Microbiol) Vol. 13 Issue 1 Pg. 28-41 (Jan 2015) ISSN: 1740-1534 [Electronic] England
PMID25417656 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Ribonucleoproteins
  • Viral Proteins
Topics
  • Host-Pathogen Interactions
  • Humans
  • Influenza A virus
  • Influenza, Human
  • Ribonucleoproteins
  • Viral Proteins

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