Severity grading of chronic obstructive pulmonary disease: the confounding effect of phenotype and thoracic gas compression.

Abstract

Current guidelines recommend severity of chronic obstructive pulmonary disease be graded by using forced expiratory volume in 1 s (FEV1). But this measurement is biased by thoracic gas compression depending on lung volume and airflow resistance. The aim of this study was to test the hypothesis that the effect of thoracic gas compression on FEV1 is greater in emphysema than chronic bronchitis because of larger lung volumes, and this influences severity classification and prognosis. FEV1 was simultaneously measured by spirometry and body plethysmography (FEV1-pl) in 47 subjects with dominant emphysema and 51 with dominant chronic bronchitis. Subjects with dominant emphysema had larger lung volumes, lower diffusion capacity, and lower FEV1 than those with dominant chronic bronchitis. However, FEV1-pl, patient-centered variables (dyspnea, quality of life, exercise tolerance, exacerbation frequency), arterial blood gases, and respiratory impedance were not significantly different between groups. Using FEV1-pl instead of FEV1 shifted severity distribution toward less severe classes in dominant emphysema more than chronic bronchitis. The body mass, obstruction, dyspnea, and exercise (BODE) index was significantly higher in dominant emphysema than chronic bronchitis, but this difference significantly decreased when FEV1-pl was substituted for FEV1. In conclusion, the FEV1 is biased by thoracic gas compression more in subjects with dominant emphysema than in those with chronic bronchitis. This variably and significantly affects the severity grading systems currently recommended.

• Authors: Riccardo Pellegrino, Emanuele Crimi, Alessandro Gobbi, Roberto Torchio, Andrea Antonelli, Carlo Gulotta, Michele Baroffio, Giuseppe Francesco Sferrazza Papa, Raffaele Dellacà, Vito Brusasco
• Journal: Journal of applied physiology (Bethesda, Md. : 1985) (J Appl Physiol (1985)) Vol. 118 Issue 7 Pg. 796-802 (Apr 01 2015) ISSN: 1522-1601 [Electronic] United States
• PMID: 25414244 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2015 the American Physiological Society.

Topics

• Algorithms
• Artifacts
• Diagnosis, Computer-Assisted (methods)
• Humans
• Lung (physiopathology)
• Middle Aged
• Phenotype
• Plethysmography, Whole Body (methods)
• Pulmonary Disease, Chronic Obstructive (classification, diagnosis, physiopathology)
• Reproducibility of Results
• Respiratory Function Tests (methods)
• Sensitivity and Specificity
• Severity of Illness Index
• Total Lung Capacity