Abstract | PURPOSE: To evaluate longitudinal variations of reticular drusen (RDR) in age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO), near-infrared reflectance (NIR) and spectral-domain optical coherence tomography (SD-OCT) imaging. METHODS: Eighteen eyes of 12 patients with RDR (median observational time 5 months, range 3-10) were included. Changes over time in the en face cSLO NIR images, the identical SD-OCT B scan (simple approach) and the dense SD-OCT volume scans (11 µm between B scans, detailed approach) for 5 preselected RDR lesions were analysed, respectively. RESULTS: Nineteen of 90 (21%) lesions were no longer detectable at the follow-up examination with the simple SD-OCT approach (increase 7/decrease 48/unchanged 15/not gradable 1). By contrast, no disappearance of single lesions was noted for both cSLO (3/8/61/18) and detailed SD-OCT image analysis (67/22/1/0). Within the dense SD-OCT volume scan, a median change of individual lesion height of 10 µm/year was determined. CONCLUSIONS: The findings indicate a recordable progression of RDR lesions in lateral and vertical dimensions. Using dense SD-OCT volume scans, individual RDR lesion progression can be quantified and may be applied in future longitudinal studies.
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Authors | Julia S Steinberg, Jasmin Auge, Monika Fleckenstein, Frank G Holz, Steffen Schmitz-Valckenberg |
Journal | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
(Ophthalmologica)
Vol. 233
Issue 1
Pg. 35-42
( 2015)
ISSN: 1423-0267 [Electronic] Switzerland |
PMID | 25413846
(Publication Type: Journal Article)
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Copyright | © 2014 S. Karger AG, Basel. |
Topics |
- Aged
- Aged, 80 and over
- Disease Progression
- Female
- Follow-Up Studies
- Geographic Atrophy
(diagnosis)
- Humans
- Male
- Microscopy, Confocal
- Prospective Studies
- Retinal Drusen
(diagnosis)
- Tomography, Optical Coherence
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