Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines.

Abstract

Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.

• Authors: Ivan Montenegro, Giacomo Tomasoni, Claudia Bosio, Natalia Quiñones, Alejandro Madrid, Hector Carrasco, Andres Olea, Rolando Martinez, Mauricio Cuellar, Joan Villena
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 19 Issue 11 Pg. 18993-9006 (Nov 18 2014) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 25412045 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Furans
• Polycyclic Sesquiterpenes
• Sesquiterpenes
• Terpenes
• Tetrahydronaphthalenes
• confertifolin
• drimane
• drimenol
• polygodial

Topics

• Cell Line, Tumor
• Cell Membrane Permeability (drug effects)
• Furans (pharmacology)
• HT29 Cells
• Humans
• Inhibitory Concentration 50
• MCF-7 Cells
• Mitochondrial Membranes (drug effects)
• Neoplasms (drug therapy)
• Polycyclic Sesquiterpenes
• Sesquiterpenes (pharmacology)
• Terpenes (pharmacology)
• Tetrahydronaphthalenes (pharmacology)