Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: Of the children in the study, 57.4% had at least 1 elevated APP, and 48.5% had elevated HRP2. After adjusting for APP, children with elevated HRP2 had higher pF (23.5 ± 1.5 μg/L vs. 11.1 ± 0.8 μg/L; P < 0.001) and lower RBP (0.79 ± 0.01 μmol/L vs. 0.92 ± 0.01 μmol/L; P < 0.001) than those without, but there were no differences in pZn among those with and without elevated HRP2 (64.9 ± 12.7 μg/dL vs. 64.9 ± 11.1 μg/dL; P = 0.98). Children with elevated HRP2 had higher sTfR than those without (17.6 ± 0.5 mg/L vs. 12.3 ± 0.4 mg/L; P < 0.0001). After adjusting for HRP2, along with APP, the estimated prevalence of iron deficiency (pF < 12 μg/L) increased from 38.7% to 50.6% and vitamin A deficiency (RBP < 0.84 μmol/L) decreased from 33.4% to 27.7%. CONCLUSIONS: Asymptomatic malaria is associated with indicators of micronutrient status, even after adjusting for APP. Adjusting indicators of iron and vitamin A status based only on APP may inaccurately estimate the prevalence of micronutrient deficiencies in settings with a high prevalence of malaria and inflammation. This trial was registered at clinicaltrials.gov as NCT00944853.
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Authors | K Ryan Wessells, Sonja Y Hess, Zinewendé P Ouédraogo, Noel Rouamba, Jean-Bosco Ouédraogo, Kenneth H Brown |
Journal | The Journal of nutrition
(J Nutr)
Vol. 144
Issue 12
Pg. 2050-8
(Dec 2014)
ISSN: 1541-6100 [Electronic] United States |
PMID | 25411038
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 American Society for Nutrition. |
Chemical References |
- Acute-Phase Proteins
- Biomarkers
- Hemoglobins
- Iron, Dietary
- Micronutrients
- Orosomucoid
- Proteins
- Retinol-Binding Proteins
- histidine-rich proteins
- Vitamin A
- C-Reactive Protein
- Ferritins
- Zinc
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Topics |
- Acute-Phase Proteins
(metabolism)
- Acute-Phase Reaction
(blood)
- Adolescent
- Anemia, Iron-Deficiency
(epidemiology)
- Asymptomatic Diseases
(epidemiology)
- Biomarkers
(blood)
- Burkina Faso
- C-Reactive Protein
(metabolism)
- Child
- Cross-Sectional Studies
- Dietary Supplements
- Female
- Ferritins
(blood)
- Hemoglobins
(metabolism)
- Humans
- Iron, Dietary
(administration & dosage)
- Linear Models
- Malaria
(blood, diagnosis, epidemiology)
- Male
- Micronutrients
(blood)
- Nutritional Status
- Orosomucoid
(metabolism)
- Prevalence
- Proteins
(metabolism)
- Randomized Controlled Trials as Topic
- Retinol-Binding Proteins
(metabolism)
- Vitamin A
(administration & dosage, blood)
- Vitamin A Deficiency
(epidemiology)
- Zinc
(administration & dosage, blood)
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