Abstract | IMPORTANCE: OBSERVATIONS: CONCLUSIONS AND RELEVANCE: This is the first report of dihydrocodeine phosphate-induced AGEP. In this case, helper T cells, type 17, might have been activated because of morphine and underlying PV, followed by increased production of interleukin (IL) 36. However, because of the IL36RN mutation, IL-36 signaling was uncontrolled, which might have resulted in the occurrence of AGEP. An IL36RN mutation might underlie several different pustular skin eruptions, including AGEP and GPP, and further accumulation of patient data is required.
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Authors | Noriaki Nakai, Kazumitsu Sugiura, Masashi Akiyama, Norito Katoh |
Journal | JAMA dermatology
(JAMA Dermatol)
Vol. 151
Issue 3
Pg. 311-5
(Mar 2015)
ISSN: 2168-6084 [Electronic] United States |
PMID | 25409173
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Analgesics, Opioid
- IL36RN protein, human
- Interleukins
- dihydrocodeine
- Codeine
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Topics |
- Acute Generalized Exanthematous Pustulosis
(etiology, genetics, pathology)
- Analgesics, Opioid
(adverse effects)
- Codeine
(adverse effects, analogs & derivatives)
- Female
- Heterozygote
- Humans
- Interleukins
(genetics)
- Middle Aged
- Psoriasis
(genetics, pathology)
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